Stage IV Breast Cancer Incidence and Survival, 2010-2021

What were the changes in the incidence, percentage, and survival of individuals with de novo stage IV breast cancer diagnosed from 2010 through 2021?In this cohort study of 761 471 individuals with breast cancer, the incidence of stage IV breast cancer increased significantly by 1.2% per year, and the percentage of people with stage IV also increased significantly. Stage IV incidence increased widely across all ages, races, sexes, and tumor subtypes, while survival improved significantly from 2010 through 2021.These findings suggest that efforts are needed to determine factors contributing to these increases and to identify breast cancer before patients present with de novo stage IV disease.

Corresponding Author: José P. Leone, MD, Department of Medical Oncology, Susan F. Smith Center for Women’s Cancer, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA 02215 (josep_leone@dfci.harvard.edu).

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