SARS-CoV-2 Infection and Rates of Neonatal Congenital Anomalies

Is confirmed maternal SARS-CoV-2 infection during pregnancy associated with increased risk of neonatal congenital anomalies?In this population-based matched cohort study of 5049 live births with corresponding maternal SARS-CoV-2 infection in pregnancy matched to 20 196 live births without maternal infection, there was no association between maternal SARS-CoV-2 infection and neonatal congenital anomalies overall or by specific trimester of exposure.These findings suggest that SARS-CoV-2 infection during pregnancy is unlikely to increase the risk of congenital anomalies.

Corresponding Author: John W. Snelgrove, MD, MSc, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, 700 University Ave, Rm 3-915, Toronto, ON M5G 1Z5, Canada (john.snelgrove@sinaihealth.ca).

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