Pregestational Cardiometabolic Biomarkers and Future Hypertensive Disorders of Pregnancy

Are pregestational cardiometabolic disturbances associated with risk of hypertensive disorders of pregnancy (HDP)?In this cohort study including 35 189 nulliparous women, pregestationally assessed cardiometabolic biomarkers were associated with an increased risk of HDP. For some lipid and glucose biomarkers, subclinical levels (below established clinical thresholds) were associated with an increased HDP risk for a future pregnancy.These results may contribute to early identification of women at risk of HDP and suggest a need for the use of cardiometabolic biomarkers in preconceptional counseling and at enrollment in antenatal care.

Corresponding Author: Karin Leander, PhD, Institute of Environmental Medicine, Unit of Cardiovascular and Nutritional Epidemiology, Karolinska Institutet, Nobels väg 13, Box 210, 171 77 Stockholm Sweden (karin.leander@ki.se).

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