Incidence of Adverse Events in Peripheral Intravenous Vasopressor Use
JAMA Network Open 10.1001/jamanetworkopen.2026.0710March 16, 2026 at 11:00 AM EDT
What is the incidence of adverse events (AEs) and avoidance of central venous catheter (CVC) placement after peripheral intravenous (PIV) administration of vasopressors in adults?In this systematic review and meta-analysis of 49 studies including 33 060 catheters, pooled incidence of minor AEs for all PIV vasopressors was 2%, while pooled incidence of major AEs was 1% for midline and 0% for short PIV catheters. Pooled incidence of CVC avoidance was 60%.In this study, the incidence of AEs after short-term vasopressor administration through PIV catheters was low, and the findings suggest that with appropriate monitoring, PIV administration might reduce the need for CVC placement.
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