Original Investigation

Incidence of Adverse Events in Peripheral Intravenous Vasopressor Use

JAMA Network Open 10.1001/jamanetworkopen.2026.0710

March 16, 2026 at 11:00 AM EDT

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What is the incidence of adverse events (AEs) and avoidance of central venous catheter (CVC) placement after peripheral intravenous (PIV) administration of vasopressors in adults?In this systematic review and meta-analysis of 49 studies including 33 060 catheters, pooled incidence of minor AEs for all PIV vasopressors was 2%, while pooled incidence of major AEs was 1% for midline and 0% for short PIV catheters. Pooled incidence of CVC avoidance was 60%.In this study, the incidence of AEs after short-term vasopressor administration through PIV catheters was low, and the findings suggest that with appropriate monitoring, PIV administration might reduce the need for CVC placement.

Corresponding Author: Chieh-Ching Yen, MD, Department of Emergency Medicine, New Taipei Municipal Tucheng Hospital, No. 6, Sec. 2, Jincheng Rd., Tucheng District, New Taipei City 236, Taiwan ROC (chiehching74@gmail.com).

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