Genetic Testing for in Adults With Hypertension

Among participants with hypertension with an apolipoprotein L1 locus ) high-risk genotype, would immediate genetic return of results vs no genetic testing until trial conclusion result in a greater improvement in systolic blood pressure (SBP) at 3 months?This randomized clinical trial including 6754 participants found that, at 3 months, there was no difference in SBP between those with immediate and delayed results; however, among participants with uncontrolled blood pressure, those who received immediate results saw a greater reduction in SBP than those with a delay. Provision of genotype also led to increased urine microalbumin screening and chronic kidney disease diagnoses at 6 months.This study suggests that immediate provision of results to participants and clinicians was not associated with SBP reduction, but genotyping increased the rate of CKD screening and diagnosis.

Corresponding Author: Carol R. Horowitz, MD, MPH, Institute for Health Equity Research, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, 7th Floor, New York, NY 10029 (carol.horowitz@mountsinai.org).

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