Original Investigation

Understanding of Prognosis and Estimation of Mortality in Ambulatory Patients With Heart Failure

JAMA Network Open 10.1001/jamanetworkopen.2026.0328

March 03, 2026 at 11:00 AM EST

Read the full article

How well do ambulatory patients with high-risk heart failure (HF) with reduced ejection fraction estimate their own survival compared with a validated, guideline-endorsed risk score, and is overestimation associated with mortality?In this cohort study of 296 patients with chronic HF, 33% overestimated their life expectancy by more than 50% compared with model estimates, and such overestimation was associated with higher mortality in the subsequent 2 years.The findings suggest improving patient understanding of prognosis may enhance shared decision-making for patients with high-risk ambulatory HF.

Corresponding Author: Thomas M. Cascino, MD, MSc, Division of Cardiovascular Medicine, University of Michigan, 2381 CVC SPC 5853, 1500 E Medical Center Dr, Ann Arbor, MI 48109-5853 (tcascino@med.umich.edu).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.

Editor's Picks