Original Investigation

Transient Global Amnesia and High-Grade Styloidogenic Jugular Vein Stenosis

JAMA Network Open 10.1001/jamanetworkopen.2026.0065

February 26, 2026 at 11:00 AM EST

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Could styloidogenic jugular vein compression (SJVC) severity represent a novel adjunctive imaging risk factor associated with a transient global amnesia (TGA) diagnosis?In this case-control study of 84 patients, right-sided SJVC stenosis (70% vs 52%) and combined right and left stenosis (68% vs 55%) were significantly greater in patients with TGA vs healthy controls.The findings of this study suggest that TGA is associated with high-grade SJVC in patients with small-caliber internal jugular veins, with a right-sided or bilateral stenosis of approximately 70% as a potential risk factor for TGA.

Corresponding Author: Tarik F. Massoud, MD, PhD, Department of Radiology, Stanford University Center for Academic Medicine, 453 Quarry Rd, Radiology, MC 5659, Palo Alto, CA 94304 (tmassoud@stanford.edu).

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