Sleep Apnea-Specific Hypoxic Burden and Postoperative Outcomes of Major Noncardiothoracic Surgery

Is there an association between the sleep apnea–specific hypoxic burden (SASHB) and 30-day postoperative mortality and cardiovascular (CV) morbidity among patients with obstructive sleep apnea (OSA) undergoing major noncardiothoracic surgery?In this cohort study that included 2286 patients with OSA undergoing major noncardiothoracic surgery, the rate of a composite outcome of postoperative complications (all-cause mortality, stroke, atrial fibrillation, heart failure, myocardial infarction, and venous thrombo-embolism) increased significantly from 1.6% in patients with low SASHB (<32% min/h) to 5.8% in those with high SASHB (≥80% min/h) at diagnosis.These findings suggest that among OSA patients undergoing major noncardiothoracic surgery, SASHB was significantly associated with the risk of 30-day postoperative mortality and CV complications.

Corresponding Author: Sébastien Bailly, PharmD, PhD, University Grenoble Alpes, Inserm, CHU Grenoble Alpes, HP2, 6, Chemin Saint Ferjus, 38700 La Tronche, Grenoble, France (sbailly@chu-grenoble.fr).

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