Morphine Plus Placebo vs Morphine Plus Acetaminophen for Acute Pain in the Emergency Department

Among adults seen in the emergency department with acute pain, does morphine plus placebo provide noninferior initial pain relief compared with morphine plus acetaminophen?In this randomized clinical trial involving 430 patients, differences in pain scores after treatment with intravenous morphine plus placebo vs intravenous morphine plus acetaminophen did not meet the prespecified noninferiority margin of 1 point in patients with either traumatic or nontraumatic pain.In this study, morphine plus placebo did not demonstrate noninferiority to morphine plus acetaminophen for initial pain relief.

Corresponding Author: Emmanuel Montassier, MD, PhD, Service des Urgences, Nantes Université, Centre Hospitalier Universitaire Nantes, 1 place Alexis Ricordeau, 40093 Nantes Cedex 1, France (emmanuel.montassier@chu-nantes.fr).

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