Original Investigation

Electronic Health Record Alerts for Early Human Papillomavirus Vaccination

JAMA Network Open 10.1001/jamanetworkopen.2025.59670

February 16, 2026 at 11:00 AM EST

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Are electronic health record (EHR) alerts with or without clinician education associated with early human papillomavirus (HPV) vaccination (ie, vaccination among youths aged 9 to 10 years)?In this quality improvement study of 15 743 youths, EHR alerts with clinician education were associated with a 39% higher likelihood of early HPV vaccine initiation compared with alerts alone.These results suggest that a light-touch intervention such as EHR alerts combined with clinician education may be sufficient to shift HPV vaccination to ages 9 and 10 years.

Corresponding Author: Jenell S. Coleman, MD, MPH, Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine, 733 N Broadway, Baltimore, MD 21205 (jenell.coleman@jefferson.edu).

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