Original Investigation

Cognitive Resilience Training to Prevent PTSD and Major Depressive Disorder in Paramedic Recruits

JAMA Network Open 10.1001/jamanetworkopen.2025.57241

February 09, 2026 at 11:00 AM EST

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Is training that targets modifiable risk factors for posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) in paramedics associated with lower rates of these disorders at 1-year follow-up compared with psychoeducation and standard practice?In this randomized clinical trial of 570 student paramedics, participants who received internet-delivered cognitive training in resilience (iCT-R) over 6 weeks had a statistically significant reduction in and significantly lower odds of developing PTSD and MDD diagnoses at follow-up.These findings suggest that iCT-R reduces the likelihood of developing common psychiatric disorders associated with paramedic training and work.

Corresponding Author: Jennifer Wild, DClinPsy, Department of Experimental Psychology, University of Oxford, Life and Mind Building, Oxford OX1 3EL, United Kingdom (jennifer.wild@psy.ox.ac.uk).

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