Original Investigation

Risk of Cardiorespiratory Events Following Respiratory Syncytial Virus–Related Hospitalization

JAMA Network Open 10.1001/jamanetworkopen.2025.56767

February 03, 2026 at 11:00 AM EST

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Is the risk of cardiorespiratory events elevated in the 180 days following respiratory syncytial virus (RSV)–related hospitalization in adults?In this self-controlled case series study of 11 887 patients, the risk of cardiorespiratory events after RSV-related hospitalization (especially during the first 2 weeks), including myocardial infarction, stroke, chronic obstructive pulmonary disease exacerbation, congestive heart failure exacerbation, and arrhythmia, was significantly higher than during the control period. This risk remained elevated up to 180 days for some cardiorespiratory events.The findings of this study highlight the extended RSV disease burden and the need to increase RSV immunization in adults.

Corresponding Author: Caihua Liang, MD, PhD, Pfizer Inc, 66 Hudson Blvd E, New York, NY 10001 (caihua.liang@pfizer.com).

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