Traumatic Brain Injury and All-Cause and Dementia-Related Mortality in the Framingham Heart Study

What is the incidence of traumatic brain injury (TBI), and is TBI associated with long-term all-cause and dementia-related mortality?In this cohort study of 10 333 participants in the Framingham Heart Study followed from 1948 to 2022, TBI most often occurred in late life due to falls, with an incidence of 7.02 (original cohort) and 9.11 (offspring cohort) TBI events per 1000 person-years. TBI was associated with increased all-cause and dementia-related mortality but not with non–dementia-related mortality.The findings of this study suggest that preventing falls to reduce TBI could have important implications for dementia and mortality.

Corresponding Author: Jesse Mez, MD, MS, Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, 72 E Concord St, L-522 Instructional Building, Boston, MA 02118 (jessemez@bu.edu).

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