Metformin, Maternal Glycemic Control, and Neonatal Hypoglycemia After Antenatal Steroids

Does metformin treatment after betamethasone administration improve maternal glycemic control and reduce the incidence of neonatal hypoglycemia in preterm infants?In this randomized clinical trial of 169 pregnant women receiving betamethasone, metformin significantly improved maternal glycemic control and reduced the incidence of neonatal hypoglycemia compared with standard care, indicating a potential therapeutic benefit in this population.Metformin may be a safe and effective strategy to prevent betamethasone-induced maternal hyperglycemia and neonatal hypoglycemia in preterm births.

Corresponding Author: Enav Yefet, MD, PhD, Department of Obstetrics and Gynecology, Tzafon Medical Center, Poria 1528001, Israel (enavy1@gmail.com).

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