Liver Metastases and Survival Among Patients With Colorectal Cancer
JAMA Network Open 10.1001/jamanetworkopen.2025.50467December 22, 2025 at 11:00 AM EST
How has the incidence, characteristics, and survival of colorectal liver metastases (CRLM) changed over time in Denmark?In this cohort study of 14 785 patients with CRLM, the cumulative incidence of CRLM decreased across all age groups over time. Survival increased for patients with synchronous CRLM and early metachronous CRLM but not for those with late metachronous CRLM.These results support the need for targeted follow-up and treatment strategies based on the timing of metastasis.
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