Subsequent Meningiomas Among Survivors of Childhood Cancer

What are the incidence, risk factors, and mortality for single and multiple meningiomas among survivors of childhood cancer?In this cohort study of 24 886 survivors in the Childhood Cancer Survivor Study cohort, 471 survivors were diagnosed with 710 meningiomas; 35 after primary cancer diagnosis, the cumulative incidence of a subsequent meningioma was 2.3%. Meningioma risk was associated with high doses of radiation therapy, young age at primary cancer diagnosis, female sex, and exposure to platinum, antimetabolite chemotherapy, and intrathecal chemotherapy, and high rates of all-cause mortality were observed following meningioma diagnosis.These findings suggest that certain high-risk populations of childhood cancer survivors may be suitable candidates for screening for subsequent meningiomas.

Corresponding Author: Daniel C. Bowers, MD, Division of Pediatric Hematology/Oncology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical School, 5323 Harry Hines Blvd. Dallas, TX, 75390 (Daniel.Bowers@utsouthwestern.edu).

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