Prebiopsy Steroids and Diagnostic Yield in Patients With Diffuse Large B-Cell Lymphoma

Is corticosteroid administration before biopsy associated with diagnostic yield in adult patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL)?In this cohort study of 320 patients with DLBCL, diagnostic yield did not significantly differ between those who received corticosteroids before biopsy and those who did not. There was no statistically significant association between diagnostic yield and steroid dose, duration, type, or withdrawal status.These findings suggest that corticosteroids may be safely administered before biopsy in symptomatic patients with DLBCL without compromising diagnostic accuracy or delaying treatment initiation.

Corresponding Author: Sathwik Madireddy, MD, Brown University Health, 593 Eddy St, Providence, RI 02903 (sathwik_madireddy@brown.edu).

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