Awake Prone Positioning in Patients With COVID-19 Respiratory Failure

What are the effects of awake prone positioning on the incidence of intubation and/or death in nonintubated patients with COVID-19 and hypoxemic respiratory failure?In this randomized clinical trial of 445 patients, the posterior probability that APP decreased intubation and/or death over the first 28 days of admission compared with standard care was high at 93.8%.Findings of this trial support the use of awake prone positioning in patients with hypoxemic pneumonia due to COVID-19 infection.

Corresponding Author: Anatole Harrois, MD, PhD, Service d’Anesthésie Réanimation Chirurgicale, 78, rue du Général Leclerc, 94270 Le Kremlin-Bicêtre, France (anatole.harrois@aphp.fr).

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