Obstructive Coronary Artery Disease and Health Status in Transcatheter Aortic Valve Replacement

Is the presence of obstructive coronary artery disease (CAD) associated with clinical outcomes and health status among patients with symptomatic severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR)?In a post hoc analysis of the SCOPE I randomized clinical trial including 732 patients, no statistically significant differences were observed between patients with vs without obstructive CAD in patient-reported health status, mortality, and clinical efficacy according to Valve Academic Research Consortium-3 (VARC-3) definitions of TAVR throughout 3 years of follow-up.These findings suggest that concomitant CAD may not adversely affect survival, patient-reported health status, or VARC-3 clinical efficacy in patients with AS undergoing TAVR.

Corresponding Author: Thomas Pilgrim, MD, MSc, Department of Cardiology, Bern University Hospital, Inselspital, University of Bern, CH-3010 Bern, Switzerland (thomas.pilgrim@insel.ch).

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