Angiogenesis Inhibitors and Arterial Dissection or Aneurysm in Patients With Metastatic Colorectal Cancer

Are angiogenesis inhibitors associated with arterial dissections or aneurysms among patients with metastatic colorectal cancer?This nested case-control study of 2145 patients from a cohort of patients initiating targeted therapy (angiogenesis or epidermal growth factor receptor inhibitors) for metastatic colorectal cancer, found a low incidence of arterial dissections or aneurysms (0.6%) and no association between exposure to angiogenesis inhibitors and the occurrence of these events after adjustment for cardiovascular risk level.These findings suggest that the established benefits of antiangiogenic drugs in metastatic colorectal cancer appear to outweigh the potential risk of arterial dissections and aneurysms in these patients.

Corresponding Author: Pernelle Noize, PharmD, PhD, Inserm UMR 1219, Bordeaux Population Health, Équipe AHeaD, Université de Bordeaux, case 121, 146 rue Léo Saignat, 33076 Bordeaux cedex, France (pernelle.noize@u-bordeaux.fr).

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