Original Investigation

Estimation of Mortality via the Neighborhood Atlas and Reproducible Area Deprivation Indices

JAMA Network Open 10.1001/jamanetworkopen.2025.46800

January 12, 2026 at 11:00 AM EST

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How do calculation errors, such as failing to standardize variables, in the Neighborhood Atlas Area Deprivation Index (NA-ADI) lead to differences relative to the corrected Reproducible ADI (ReADI), and to what extent are these errors associated with mortality?In this cross-sectional study, the ReADI provided a corrected, multidimensional, and reliable measure of area deprivation, aligning better with other indices and improving estimates of association with mortality compared with the NA-ADI.These findings suggest that the ReADI is an accurate, transparent, and policy-relevant measure that is more suitable than the NA-ADI for guiding health equity research and resource allocation.

Corresponding Author: David H. Rehkopf, ScD, MPH, Stanford University, 1701 Page Mill Rd, Room 229, Palo Alto, CA 94304 (drehkopf@stanford.edu).

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