Seven-Day vs Four-Day Infusion Set Replacement Interval and Catheter-Related Infections

Is adopting a 7-day infusion set replacement interval for catheter-related bloodstream infections cost-effective, without increasing infection risk, compared with the standard practice of 4-day replacement intervals?In this economic evaluation including 2941 patients in the RSVP (Replacement at Standard vs Prolonged Interval) trial, replacing infusion sets at 7 instead of 4 days was associated with reduced costs but increased risk of catheter-related bloodstream infections. There was a 50.3% likelihood of cost-effectiveness and 72.5% likelihood of worse health outcomes.Results of this study suggest that there is a need for full cost-effectiveness analyses to assess the trade-off between the changes to total costs and health outcomes.

Corresponding Author: Nicholas Graves, PhD, Programme in Health Services Research and Population Health, Duke-NUS Medical School, Eight College Rd, Singapore 169857 (n.graves@duke-nus.edu.sg).

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