Combined Gastric Electrical Stimulation and Pyloroplasty in Gastroparesis
JAMA Network Open 10.1001/jamanetworkopen.2025.46332December 09, 2025 at 11:00 AM EST
Does combining gastric electrical stimulation (GES) with pyloroplasty offer additional clinical benefits for patients with refractory gastroparesis?In this randomized clinical trial on combining pyloroplasty with GES in 38 adults with refractory gastroparesis, the improvement from baseline in gastroparesis symptom scores was significantly greater in the group with GES turned on after surgery compared with the group in which it was kept off for 3 months.The findings of this study suggest that the combination of GES and pyloroplasty yields superior outcomes compared with pyloroplasty alone for refractory gastroparesis treatment by reducing symptoms safely and effectively.
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