Special Communication

A Clinical Practice Guideline for the Management of Pregnancy Alloimmunized to Red Blood Cell Antigens

JAMA Network Open 10.1001/jamanetworkopen.2025.44649

November 24, 2025 at 11:00 AM EST

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These recommendations provide an updated approach to the management of red blood cell alloimmunized pregnancies. The lack of high-quality evidence limits the strength of the recommendations but points to the need for a standardized approach to this rare disease.

Corresponding Author: Kenneth J. Moise Jr, MD, Comprehensive Fetal Care Center at Dell Children’s Medical Center, 4910 Muller Blvd, Ste 103, Austin, TX 78723 (Kmoise@austin.utexas.edu).

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