Original Investigation

Placental Vascular Resistance and Offspring Growth From Birth to Age 2 Years

JAMA Network Open 10.1001/jamanetworkopen.2025.43365

November 12, 2025 at 11:00 AM EST

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What is the association of placental vascular resistance with children’s physical growth after birth?This cohort study in 52 660 mother-infant pairs found that elevated placental vascular resistance was associated with higher risks of underweight and impaired growth during early childhood.These findings suggest the importance of routinely monitoring Doppler indices during prenatal checkups while remaining vigilant regarding the risk of impaired growth in children with elevated placental vascular resistance.

Corresponding Authors: Aifen Zhou, PhD (april1972@163.com), and Chao Xiong, PhD (xiongchao@zgwhfe.com), Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, No. 100 Hong Kong Rd, Jiang’an District, Wuhan 430016, China.

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