Original Investigation

Long-Term Health and Cost Outcomes of a 24-Week Multicomponent Frailty Intervention in Older Adults

JAMA Network Open 10.1001/jamanetworkopen.2025.43278

November 12, 2025 at 11:00 AM EST

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What are the long-term health and cost outcomes associated with a 24-week multicomponent frailty intervention for socioeconomically vulnerable older adults in rural Korea?In this economic evaluation of a nonrandomized trial of 119 matched pairs of older adults, participants had significantly longer survival free from death or long-term care eligibility and significantly lower cumulative health service-use costs ($7688 per person) over 66 months, yielding a cost:benefit ratio of 8.82.This economic evaluation found that the 24-week multicomponent intervention was associated with sustained health and cost benefits in older adults, supporting broader implementation.

Corresponding Authors: Hojoon Sohn, MPH, PhD, Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, Korea (hsohn@snu.ac.kr); Il-Young Jang, MD, PhD, Department of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, 115 Irwon-ro, Gangnam-gu, Seoul, 06355Korea (onezero2@gmail.com).

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