Cord Blood Appetite Hormones and Early-Life Growth and Childhood Adiposity in the ENVIRONAGE Cohort

Are cord blood levels of appetite hormones associated with early-life growth patterns and childhood adiposity?In this birth cohort study of 325 children, cord blood peptide YY and pancreatic polypeptide levels were associated with rapid growth in early life and a higher body mass index score at 4 to 6 years of age, whereas leptin levels were inversely associated with rapid growth.These results suggest that cord blood appetite hormone levels may contribute to early childhood growth and adiposity, potentially influencing the development of obesity.

Corresponding Author: Tim S. Nawrot, PhD, Centre for Environmental Sciences, Hasselt University, Agoralaan Bldg D, 3590 Diepenbeek, Belgium (tim.nawrot@uhasselt.be).

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