Original Investigation

Prenatal Care and Perinatal Regionalization for Congenital Heart Defects

JAMA Network Open 10.1001/jamanetworkopen.2025.42135

November 09, 2025 at 1:30 PM EST

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What is the association between prenatal care initiation, prenatal visit frequency, and delivery location for neonates with congenital heart defects (CHDs)?In this cross-sectional study of 12 113 neonates born with CHDs in Illinois, delayed prenatal care initiation was associated with increased probability of delivery at a cardiac center compared with no prenatal care. Furthermore, for those with mild CHDs, more prenatal visits were associated with a 6.7 percentage point decrease in probability of delivery at a cardiac center.These findings suggest that prenatal care initiation and visit frequency may both influence risk-appropriate care among neonates with CHDs.

Corresponding Author: Joyce Woo, MD, MS, Division of Cardiology, Ann and Robert H. Lurie Children’s Hospital of Chicago, 225 E Chicago Ave, Box 21, Chicago, IL 60611 (jwoo@luriechildrens.org).

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