Prenatal Glucose Intolerance and Child Neurodevelopmental Disorders

Do associations between prenatal glucose intolerance and neurodevelopmental disorders, including autism spectrum disorder and developmental delay, differ by gestational timing of exposure and child sex?In this case-control study of 4546 mother-child pairs, gestational diabetes diagnosed earlier in pregnancy was associated with increased odds of autism spectrum disorderamong female children only. Prenatal exposure to subclinical impaired glucose tolerance was associated with increased odds of developmental delay, also among females only.These findings suggest that evidence for sex differences in the associations of both gestational diabetes and prenatal impaired glucose tolerance with risk of child neurodevelopmental disorders.

Corresponding Author: Luke P. Grosvenor, PhD, Division of Research, Kaiser Permanente Northern California, 4480 Hacienda Dr, Pleasanton, CA 94588 (luke.p.grosvenor@kp.org).

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