Original Investigation

Eppikajutsuto for Treatment of Lymphatic Malformations in Children

JAMA Network Open 10.1001/jamanetworkopen.2025.40897

November 03, 2025 at 11:00 AM EST

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Is eppikajutsuto, a traditional Japanese (Kampo) herbal medicine, associated with reduced lesion volume among children with lymphatic malformations (LMs)?In this nonrandomized clinical trial of 19 children with LMs, 10 (53%) achieved a 20% or greater reduction in lesion volume at 6 months. No serious adverse events were reported.These findings suggest that eppikajutsuto was associated with a reduction in lesion volume and was well tolerated in children with LMs.

Corresponding Author: Keiko Ogawa-Ochiai, MD, PhD, Kampo Clinical Center, Hiroshima University Hospital, Hiroshima Daigaku Byoin, Kasumi 1-2-3, Minami-ku, Hiroshima, Hiroshima 734-8551, Japan (okeiko22@hiroshima-u.ac.jp).

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