Eppikajutsuto for Treatment of Lymphatic Malformations in Children
JAMA Network Open 10.1001/jamanetworkopen.2025.40897November 03, 2025 at 11:00 AM EST
Is eppikajutsuto, a traditional Japanese (Kampo) herbal medicine, associated with reduced lesion volume among children with lymphatic malformations (LMs)?In this nonrandomized clinical trial of 19 children with LMs, 10 (53%) achieved a 20% or greater reduction in lesion volume at 6 months. No serious adverse events were reported.These findings suggest that eppikajutsuto was associated with a reduction in lesion volume and was well tolerated in children with LMs.
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