Nirsevimab Treatment of RSV Bronchiolitis in Pediatric Emergency Departments
JAMA Network Open 10.1001/jamanetworkopen.2025.40720October 30, 2025 at 11:00 AM EDT
Did the effectiveness of nirsevimab treatment in preventing respiratory syncytial virus (RSV) type B bronchiolitis during pediatric emergency department visits remain stable during the second season of implementation?In this test-negative case-control study of 636 infants, the estimated effectiveness of nirsevimab treatment was 83.2% during the first season of implementation and 89.3% during the second season.This study suggests that, although RSV type B resistant strains had been recently identified, the effectiveness of nirsevimab treatment at preventing RSV type B bronchiolitis remained high during the second season of national implementation in France.
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