Schizophrenia, Bipolar, or Major Depressive Disorder and Postacute Sequelae of COVID-19

Do adults with serious mental illnesses (schizophrenia, bipolar disorder, or recurrent major depressive disorder) have an increased risk of developing postacute sequelae of SARS-CoV-2 (PASC)?This cohort study of 1.6 million patients found that adults with serious mental illnesses had increased adjusted odds of developing PASC. Older individuals and those with non-Hispanic Black or Hispanic race and ethnicity, public health insurance, higher chronic disease burden, and greater severity of the initial COVID-19 infection had higher odds of PASC.These results suggest the need for coordinated approaches that simultaneously treat and seek to prevent PASC among adults with serious mental illnesses.

Corresponding Author: Jyotishman Pathak, PhD, Weill Cornell Medicine, 575 Lexington Ave, 6th Floor, New York, NY 10022 (jyp2001@med.cornell.edu).

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