Original Investigation

Integrating Multimodal Neuroimaging of Error Monitoring to Estimate Future Anxiety in Adolescents

JAMA Network Open 10.1001/jamanetworkopen.2025.39133

October 23, 2025 at 11:00 AM EDT

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Does integrating electroencephalogram (EEG)-based and functional magnetic resonance imaging (fMRI)-based measures of error monitoring improve estimation of future anxiety changes during adolescence?In this cohort study of 176 adolescents, only error monitoring scores derived from a novel EEG-fMRI fusion approach were associated with improved estimation of future anxiety changes. The EEG-fMRI fusion scores explained additional variance in later anxiety scores over and above demographic information, baseline anxiety, EEG-only measures, and fMRI-only measures.Findings of this study suggest that integrating the complementary temporal and spatial precision of EEG and fMRI can improve estimation of adolescents’ future mental health trajectories.

Corresponding Author: Emilio Alejandro Valadez, PhD, Department of Psychology, University of Southern California, 3620 S McClintock Ave, SGM 501, Los Angeles, CA 90089 (evaladez@usc.edu).

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