Trial Enrollment and Survival Disparities Among Patients With Advanced Epithelial Ovarian Carcinoma

Do enrollment and survival outcomes vary by race among patients participating in randomized clinical trials?In this cohort study analyzing data from 4 completed randomized phase 3 trials with 1903 evaluable participants, Black patients made up 6.4% and Asian patients represented 1.8% of these trials’ populations. Overall survival (the primary end point) was lower among Black patients compared with White and Asian patients, whereas progression-free survival rates were not significantly different among racial groups.A lack of diversity was observed in clinical trials, highlighting the need for more equitable enrollment and outcomes for all patients.

Corresponding Author: Alex A. Francoeur, MD, University of California, Irvine, 3800 W Chapman Ave, Orange, CA 92868 (francoea@hs.uci.edu).

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