Preserved Cognitive Function After Statin Administration During Cancer Treatment With Doxorubicin

What is the association of atorvastatin with cognitive function in patients receiving doxorubicin for cancer treatment over 24 months?In this secondary analysis involving 238 patients from the Preventing Anthracycline Cardiovascular Toxicity With Statins randomized clinical trial, there was a significant improvement of 10.2 seconds in time to complete the Trail Making Test part B within the statin group compared with only 0.2 seconds in the placebo group; however, between-group differences were not significant. Scores for 2 additional tests of cognitive function were similar between the groups.These findings suggest that participants who receive statins during anthracycline-based cancer treatment may not experience deterioration in cognitive function.

Corresponding Author: W. Gregory Hundley, MD, Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, PO Box 980335, Richmond, VA 23298-0335 (greg.hundley@vcuhealth.org).

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