Sodium Reduction Program Incorporating Genetic Profile and an AI-Based App

Does a sodium reduction program that incorporates a genetic profile and an artificial intelligence (AI)–based smartphone app effectively reduce salt intake among adults with elevated blood pressure and a sodium-sensitive genotype?In this randomized clinical trial of 289 participants, the intervention group did not show a statistically significant reduction in salt intake after 3 months compared with either the control group or the app-only group. Secondary outcomes, including body mass index, behavior change intentions, and blood pressure, also did not differ significantly between the groups.A sodium reduction program integrating a genetic profile and an AI-based app did not result in meaningful dietary change among individuals with elevated blood pressure, suggesting limited utility of digital and genetic personalized interventions in modifying sodium-related health behaviors.

Corresponding Author: Koryu Sato, MPH, PhD, Faculty of Policy Management, Keio University, 5322 Endo, Fujisawa-shi, Kanagawa, 252-0882, Japan (koryus@keio.jp).

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