Original Investigation

Motivations, Facilitators, and Barriers of Donation-Based Interventions in HIV and Sexually Transmitted Infection Research

JAMA Network Open 10.1001/jamanetworkopen.2025.37382

October 14, 2025 at 11:00 AM EDT

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What are the motivations, facilitators, and barriers of prosocial behavior in donation-based interventions in HIV and sexually transmitted infection research?This systematic review of 27 qualitative studies of donation-based interventions, which included 1543 participants, found that givers leveraged altruism, agency, and relationality with recipients to improve distribution and use of health services in their social networks. Distributing or donating services to others could foster a prosocial identity that increased givers’ concern and responsibility for others’ health needs.Findings suggested that donation-based interventions could improve service uptake among marginalized populations using psychosocial assets already within those networks.

Corresponding Author: Joseph D. Tucker, MD, Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, 130 Mason Farm Rd, Chapel Hill, NC 27514 (jdtucker@med.unc.edu).

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