Risk of Parkinson Disease Among Patients With Restless Leg Syndrome

Is restless leg syndrome (RLS) associated with an increased risk of developing Parkinson disease (PD)?In this nationwide population-based cohort study, 9919 patients with RLS showed a statistically significantly higher risk of developing PD than those without RLS. Patients with RLS who were not treated with dopamine agonists showed a shorter time to PD diagnosis, whereas those who were treated with dopamine agonist showed longer time to PD diagnosis.This study suggests that RLS is associated with an increased risk of PD, and the association may involve mechanisms beyond the dopaminergic pathway.

Corresponding Authors: Jong Hun Kim, MD, PhD, Department of Neurology, Korea University Ansan Hospital, 123, Jeokgeum-ro, Danwon-gu, Ansan-si, Gyeonggi-do, Republic of Korea (jh7521@naver.com); Hyoung Seop Kim, MD, PhD, Medical Research Institute, Pohang Stroke and Spine Hospital, 352, Huimang-daero, Nam-gu, Pohang-si, Gyeongsangbuk-do, Republic of Korea (rehappydoc@gmail.com).

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