Original Investigation

Cardiovascular Health Changes in Young Adults and Risk of Later-Life Cardiovascular Disease

JAMA Network Open 10.1001/jamanetworkopen.2025.35573

October 06, 2025 at 11:00 AM EDT

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Are longitudinal patterns of change in cardiovascular health (CVH) through young adulthood associated with risk for incident cardiovascular disease (CVD) in later life?In this cohort study of 4241 Black and White young adults, change in CVH was assessed at population and individual levels by trajectories and status change, respectively. Unfavorable longitudinal patterns were associated with an elevated risk for incident CVD as much as 9.96 times higher than favorable patterns.These findings suggest that CVH in young adulthood is an important target for primordial prevention strategies to mitigate risk for future CVD.

Corresponding Author: Donald M. Lloyd-Jones, MD, ScM, Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University Chobanian dlloydjo@bu.edu).

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