AI-Driven Clinical Decision Support to Reduce Hospital-Acquired Venous Thromboembolism

Does a prognostic model–driven electronic health record alert recommending venous thromboembolism (VTE) prophylaxis for hospitalized adults who may be at high risk, are not receiving active prophylaxis, and do not have a contraindication reduce the incidence of hospital-acquired VTE?This trial protocol describes the Venous Thromboembolism Using AI (VTE-AI) randomized clinical trial, which will test a prognostic model–driven electronic health record–based nudge to reduce hospital-acquired VTE incidence across urban and rural hospital settings in Tennessee.The VTE-AI trial is one of the first randomized clinical trials to measure the effectiveness of health care AI–driven decision support compared with standard of care across medical and surgical services and urban and rural settings.

Corresponding Author: Colin G. Walsh, MD, MA, Vanderbilt University Medical Center, 2525 W End Ave, Ste 1475, Nashville, TN 37203 (colin.walsh@vumc.org).

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