Cost-Effectiveness of HPV Self-Testing Options for Cervical Cancer Screening

What is the cost-effectiveness of mailed human papillomavirus (HPV) self-sampling kits (direct-to-all or opt-in) relative to usual care for increasing cervical cancer screening among members of a US health care system with varying screening histories?In this economic evaluation of 31 355 participants from a randomized clinical trial, the direct mailing of HPV kits was highly cost-effective among cervical cancer screening adherent and overdue members as was an opt-in approach among members, with unknown screening histories.These findings suggest that within US-based private integrated health care systems, directly mailing HPV kits for cervical cancer screening is cost-effective and affordable.

Corresponding Author: Rachel L. Winer, PhD, MPH, Department of Epidemiology, University of Washington School of Public Health, 3980 15th Ave NE, Box 351619, Seattle, WA 98195 (rlw@uw.edu).

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