Original Investigation

Resistance Exercise Therapy After COVID-19 Infection

JAMA Network Open 10.1001/jamanetworkopen.2025.34304

November 10, 2025 at 3:10 PM EST

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What are the effects of a personalized resistance exercise intervention on physical and psychological function after COVID-19 infection?In this randomized clinical trial that included 233 adults after COVID-19 infection, the mean change in Incremental Shuttle Walk Test distance at 3 months compared with baseline was 83 m in the intervention group and 47 m in the control group, a statistically significant difference of 36.5 m. Health-related quality of life, anxiety, depression, and grip strength also improved more in the intervention group than in the control group.This study suggests that resistance exercise in a community and posthospitalized post–COVID-19 population improved physical function and psychological well-being.

Corresponding Author: Colin Berry, BSc, MBChB, PhD, British Heart Foundation Glasgow Cardiovascular Research Centre, School of Cardiovascular and Metabolic Health, University of Glasgow, 126 University Pl, Glasgow G12 8TA, Scotland (colin.berry@glasgow.ac.uk).

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