Original Investigation

Smartphone-Based Muscle Relaxation for Migraine in the Emergency Department

JAMA Network Open 10.1001/jamanetworkopen.2025.34221

October 16, 2025 at 11:00 AM EDT

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How does a smartphone-based progressive muscle relaxation (PMR) migraine self-management program impact migraine-related disability, quality of life, and monthly headache days (MHDs) in the emergency department (ED)?In this randomized clinical trial that analyzed data from 69 participants, the mean change in Migraine Disability Assessment Scale scores (baseline to 3 months) differed between groups, although no change in migraine-specific quality of life or MHDs occurred. Higher PMR use was associated with greater improvement in migraine-related disability.These findings suggest that for ED patients with migraine, the self-management program had clinically significant improvements in migraine-related disability over 3 months.

Corresponding Author: Mia T. Minen, MD, MPH, NYU Langone Health, 222 E 41st St, New York, NY 10017 (minenmd@gmail.com).

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