Factors in the Initial Resuscitation of Patients With Severe Trauma

Do fibrinogen concentrate (FC) and prothrombin complex concentrate (PCC) reduce allogeneic blood product use within 24 hours in severely injured patients with trauma compared with frozen plasma (FP)?In this randomized clinical trial involving 137 patients with massive hemorrhage protocol activation on admission, there was no significant difference in 24-hour allogeneic blood product use between those in the FC-PCC group vs the FP group.FC and PCC were not superior to FP for initial resuscitation of patients with trauma.

Corresponding Author: Luis T. da Luz, MD, MSC, Sunnybrook Health Sciences – Division of General Surgery and Tory Trauma Program, Department of Surgery, University of Toronto, 2075 Bayview Ave, Room H115, Toronto, Ontario, M4N 3M5, Canada (luis.daluz@sunnybrook.ca).

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