Chemoradiotherapy With or Without Simultaneous Integrated Boost for Cervical Cancer With Full-Thickness Stromal Invasion

Does simultaneous integrated boost (SIB) radiotherapy improve 3-year progression-free survival (PFS) among patients with postoperative cervical cancer with full-thickness and outer full-thickness stromal invasion?In this phase 3 randomized clinical trial of 466 patients, SIB radiotherapy was associated with a statistically significant improvement in 3-year PFS, with an absolute increase of 7.8% (84.6% vs 76.8%).This study suggests that SIB radiotherapy may improve overall disease control for patients in this cohort, supporting its integration into adjuvant therapy.

Corresponding Authors: Jun Zhu, MD (dragonzld@163.com), and Guihao Ke, PhD (kegh5734@126.com), Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, China.

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