Estimands for Clinical Effectiveness of Risk-Reducing Early Salpingectomy in Women With High Risk of Ovarian Cancer

What estimands are most useful for the study of clinical effectiveness of risk-reducing early salpingectomy (RRES) from prospective cohort studies?This comparative effectiveness study of 889 women used estimand and analysis options to evaluate clinical effectiveness of RRES with delayed oophorectomy, using initial data from the PROTECTOR cohort study. The preferred estimand outcome was ovarian cancer incidence after surgery, and the primary target measure was proportion of cancers prevented by RRES vs no surgery with superiority testing.This estimand differs from those in other ongoing clinical effectiveness studies and suggests a feasible recruitment target for evaluating clinical effectiveness in the PROTECTOR cohort study.

Corresponding Author: Ranjit Manchanda, PhD, Wolfson Institute of Population Health, Cancer Research UK, Barts Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, United Kingdom (r.manchanda@qmul.ac.uk).

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