PREVENT and PCE Models for Estimating ASCVD Risk Stratified by Statin Exposure

How do the Predicting Risk of Cardiovascular Disease Events (PREVENT) and Pooled Cohort Equation (PCE) models perform in estimating 10-year atherosclerotic cardiovascular disease (ASCVD) risk when accounting for statin therapy exposure?In this cohort study including 193 885 patients, among patients who were not exposed to statins during follow-up, PREVENT underestimated risk, whereas PCE provided estimates that more closely matched observed ASCVD risk.This cohort study found that compared with the PREVENT estimates, PCE estimates more closely reflected what a patient’s ASCVD risk would be without statin therapy.

Corresponding Author: Ming-Sum Lee, MD, PhD, Department of Cardiology, Kaiser Permanente Los Angeles Medical Center, 1526 N Edgemont St, 2nd Floor, Los Angeles, CA 90027 (mingsum.lee@kp.org).

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