Original Investigation

Factors Associated With Willingness to Become a Living Organ Donor

JAMA Network Open 10.1001/jamanetworkopen.2025.27592

August 19, 2025 at 11:00 AM EDT

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What factors are associated with US adults’ willingness to become a living organ donor to a family member?In this cross-sectional study of 9922 adults from the National Survey of Organ Donation Attitudes and Practices, greater knowledge of living donation, higher religiosity, and perceptions of fairness in the transplant system were associated with increased willingness to donate. Women and White participants were more likely to report willingness to donate, while Asian participants were less likely.Efforts to expand the living donor pool may benefit from targeted education and strategies that promote trust and transparency in the transplant system.

Corresponding Author: Lauren D. Nephew, MD, MA, MSCE, Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, 702 Rotary Building, Ste 225, Indianapolis, IN 46202 (lnephew@iu.edu).

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