Cervical Cancer Screening, HPV Vaccination, and Cervical Cancer Elimination

What are the estimated effects of different cervical cancer screening strategies, along with human papillomavirus (HPV) vaccination, on the goal of cervical cancer elimination?This decision analytical model, which simulated the Korean population from 2024 to 2100, found that under the current screening policy (2-year Papanicolaou testing started at age 20 years), the incidence rate was expected to decline below the World Health Organization disease elimination threshold of 4 cases per 100 000 women by 2044. In an ideal scenario with 70% screening and 90% vaccination rates, high-risk HPV testing with a 2-year interval starting at age 20 years was estimated to lead to elimination by 2034.These findings suggest that implementing high-risk HPV testing and increasing HPV vaccination rates could accelerate cervical cancer elimination.

Corresponding Author: Kui Son Choi, PhD, Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang 10408, South Korea (kschoi@ncc.re.kr).

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