Long-Term Therapy With Transcranial Magnetic Stimulation in Primary Progressive Aphasia

What is the efficacy of long-term transcranial magnetic stimulation (TMS) combined with language therapy in individuals with primary progressive aphasia (PPA)?In this randomized clinical trial, which included 63 participants diagnosed with PPA, TMS administered over a 6-month period mitigated decline in regional brain metabolism, language, and functionality.These findings suggest that long-term TMS combined with language therapy may help slow the progression of PPA and offer a new approach for the treatment of language disturbances due to neurodegenerative disorders.

Corresponding Author: Jordi A. Matias-Guiu, PhD, MD, Department of Neurology, Hospital Clínico San Carlos, San Carlos Health Research Institute, Universidad Complutense de Madrid, Professor Martin Lagos St s/n, 28040 Madrid, Spain (jordi.matias-guiu@salud.madrid.org).

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